feat: clinical-trial-assistant skill package v0.1.0

2026-08-14 18:15:04 +02:00
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--- a/PROVENANCE.md
+++ b/PROVENANCE.md
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+# Data provenance — clinical-trial-assistant
+
+Where the content of this skill package comes from, counted by
+content items (tasks, competences, tools, evidence entries, curated
+knowledge). Rendered live by Gitea:
+
+```mermaid
+%%{init: {'theme':'base','themeVariables':{'pie1':'#f9a825','pie2':'#1e88e5','pie3':'#ff355e','pie4':'#d97757','pie5':'#8e24aa','pieOuterStrokeWidth':'0px','pieSectionTextColor':'#fff'}}}%%
+pie showData
+    title Content sources — clinical-trial-assistant
+    "ESCO (occupation & competences)" : 16
+    "O*NET (tasks & tools)" : 67
+    "Job boards (market evidence)" : 89
+    "Anthropic official Claude skills" : 5
+    "External AI skill packs (mapped)" : 135
+```
+
+| Source | Items | Share | Files |
+|---|---|---|---|
+| ESCO (occupation & competences) | 16 | 5.1 % | references/profile.md, references/skills.md |
+| O*NET (tasks & tools) | 67 | 21.5 % | references/tasks.md, references/tools.md |
+| Job boards (market evidence) | 89 | 28.5 % | references/market.md (full report) + "Market evidence" headline sections |
+| Wikipedia & AI expert curation | 0 | 0.0 % | glossary, literature, usecases, intake, quality, evals/ |
+| Anthropic official Claude skills | 5 | 1.6 % | references/ai-skills.md, section "anthropics/skills" (official Claude Code skills) |
+| External AI skill packs (mapped) | 135 | 43.3 % | references/ai-skills.md (per-source attribution inside) |
+| Stack Exchange practitioner Q&A (CC-BY-SA) | 0 | 0.0 % | references/practitioner-qa.md (per-entry attribution inside) |
+
+Licensing: O*NET (USDOL/ETA, CC BY 4.0) · ESCO (© European Union) ·
+job-ad evidence via official APIs (JSearch/Adzuna) · Wikipedia content
+paraphrased with source URLs — never copied · external AI skills are
+linked, not copied (Apache-2.0/MIT/source-available, see ai-skills.md).
--- a/SKILL.md
+++ b/SKILL.md
@@ -0,0 +1,65 @@
+---
+name: clinical-trial-assistant
+description: "Occupational skill for the role 'clinical trial assistant' (also: clinical research assistant, clinical research associate). Use when the user asks for typical clinical trial assistant work such as: typical clinical trial assistant responsibilities"
+---
+
+# Clinical Trial Assistant
+
+Clinical trial assistants support clinical drug research. Collaborate with researchers and doctors in hospitals. Manage essential documents such as clinical case report forms, study protocols, and informed consent forms. File relevant logs related to side effects of medicines.
+
+## Core workflow
+
+
+## How to use this skill
+
+- Read [references/profile.md](references/profile.md) for the occupation profile and scope.
+- Consult [references/tasks.md](references/tasks.md) for the full task and activity inventory.
+- Check [references/skills.md](references/skills.md) for essential vs. optional competences.
+- Check [references/tools.md](references/tools.md) for the software commonly used in this role.
+- See [references/ai-skills.md](references/ai-skills.md) — matched external AI agent skills (per-source attribution).
+
+## Key competences (essential)
+
+- apply good clinical practices
+- clinical reports
+- clinical science
+- conduct health related research
+- evidence-based approach in general practice
+- maintain treatment records
+- manage healthcare users' data
+- medical studies
+- perform clinical coding procedures
+- professional documentation in health care
+- record data from biomedical tests
+
+## Hot technologies
+
+- eClinicalWorks EHR software
+- Epic Systems
+- MEDITECH software
+- Microsoft Excel
+- Microsoft Office software
+- Microsoft Outlook
+- Microsoft PowerPoint
+- Microsoft SharePoint
+- Microsoft Word
+
+
+<!-- hot-tech -->
+
+## Hot technologies
+
+Top tools from 38 gated job ads (see references/market.md, as of 2026-07-10):
+
+- Microsoft Office — 18 %
+- Microsoft Excel — 13 %
+- Microsoft Word — 13 %
+- Microsoft Outlook — 11 %
+- MS Office Suite — 11 %
+- CTMS — 8 %
+- Microsoft PowerPoint — 8 %
+
+<!-- hot-tech -->
+
+---
+*Sources: ESCO v1.2.1 (http://data.europa.eu/esco/occupation/82b5c6dc-6a4d-4415-80d8-5cfedfc54de7), O*NET 30.3 (29-1051.00, manual nearest match). See manifest.json for licensing/attribution.*
--- a/manifest.json
+++ b/manifest.json
@@ -0,0 +1,190 @@
+{
+  "name": "clinical-trial-assistant",
+  "title": "clinical trial assistant",
+  "version": "0.1.0",
+  "layer": "core",
+  "language": "en",
+  "generated": "2026-07-07",
+  "ids": {
+    "esco_uri": "http://data.europa.eu/esco/occupation/82b5c6dc-6a4d-4415-80d8-5cfedfc54de7",
+    "esco_code": "3213.2",
+    "isco_group": "3213",
+    "onet_soc": "29-1051.00",
+    "crosswalk_match": "manual nearest via ISCO 3213 (Pharmacists)"
+  },
+  "sources": [
+    {
+      "name": "ESCO",
+      "version": "1.2.1",
+      "url": "https://esco.ec.europa.eu/"
+    },
+    {
+      "name": "O*NET",
+      "version": "30.3",
+      "url": "https://www.onetcenter.org/",
+      "license": "CC BY 4.0"
+    }
+  ],
+  "attribution": "This package includes information from the O*NET Database (v30.3) by the U.S. Department of Labor, Employment and Training Administration (USDOL/ETA), CC BY 4.0. skillfactor is not endorsed by USDOL/ETA. ESCO data (v1.2.1) (c) European Union, used per the ESCO download conditions: https://esco.ec.europa.eu/en/use-esco/download",
+  "counts": {
+    "tasks": 0,
+    "dwas": 0,
+    "skills_essential": 11,
+    "skills_optional": 4,
+    "software": 0
+  },
+  "enrichment_ai_skills": {
+    "generated": "2026-07-14",
+    "method": "deterministic mapping (ISCO prefix + title/competence keywords)",
+    "sources": {
+      "anthropics/skills": {
+        "repo": "https://github.com/anthropics/skills",
+        "commit": "f6656c1",
+        "license": "Apache-2.0; the document skills (docx/pdf/pptx/xlsx) are source-available \u2014 see the LICENSE.txt in the upstream skill folder",
+        "skills": 2
+      },
+      "K-Dense-AI/claude-scientific-skills": {
+        "repo": "https://github.com/K-Dense-AI/claude-scientific-skills",
+        "commit": "4d97e29",
+        "license": "MIT",
+        "skills": 4
+      },
+      "foryourhealth111-pixel/Vibe-Skills": {
+        "repo": "https://github.com/foryourhealth111-pixel/Vibe-Skills",
+        "commit": "34429a8",
+        "license": "Apache-2.0",
+        "skills": 5
+      },
+      "K-Dense-AI/scientific-agent-skills": {
+        "repo": "https://github.com/K-Dense-AI/scientific-agent-skills",
+        "commit": "4d97e29",
+        "license": "MIT",
+        "skills": 4
+      },
+      "davila7/claude-code-templates": {
+        "repo": "https://github.com/davila7/claude-code-templates",
+        "commit": "fa79251",
+        "license": "MIT",
+        "skills": 10
+      },
+      "brycewang-stanford/Auto-Empirical-Research-Skills": {
+        "repo": "https://github.com/brycewang-stanford/Auto-Empirical-Research-Skills",
+        "commit": "85bf545",
+        "license": "CC-BY-4.0",
+        "skills": 8
+      },
+      "jeremylongshore/claude-code-plugins-plus-skills": {
+        "repo": "https://github.com/jeremylongshore/claude-code-plugins-plus-skills",
+        "commit": "e112938a",
+        "license": "MIT",
+        "skills": 12
+      },
+      "mohitagw15856/pm-claude-skills": {
+        "repo": "https://github.com/mohitagw15856/pm-claude-skills",
+        "commit": "876fa30",
+        "license": "MIT",
+        "skills": 2
+      },
+      "a5c-ai/babysitter": {
+        "repo": "https://github.com/a5c-ai/babysitter",
+        "commit": "44a5d58b",
+        "license": "MIT",
+        "skills": 12
+      },
+      "nexu-io/open-design": {
+        "repo": "https://github.com/nexu-io/open-design",
+        "commit": "4b66023",
+        "license": "Apache-2.0",
+        "skills": 1
+      },
+      "alirezarezvani/claude-skills": {
+        "repo": "https://github.com/alirezarezvani/claude-skills",
+        "commit": "0241f43",
+        "license": "MIT",
+        "skills": 7
+      },
+      "affaan-m/everything-claude-code": {
+        "repo": "https://github.com/affaan-m/everything-claude-code",
+        "commit": "ed38744",
+        "license": "MIT",
+        "skills": 3
+      },
+      "mukul975/Anthropic-Cybersecurity-Skills": {
+        "repo": "https://github.com/mukul975/Anthropic-Cybersecurity-Skills",
+        "commit": "673da1f",
+        "license": "Apache-2.0",
+        "skills": 1
+      },
+      "staruhub/ClaudeSkills": {
+        "repo": "https://github.com/staruhub/ClaudeSkills",
+        "commit": "3d4045d",
+        "license": "MIT",
+        "skills": 1
+      },
+      "giuseppe-trisciuoglio/developer-kit": {
+        "repo": "https://github.com/giuseppe-trisciuoglio/developer-kit",
+        "commit": "306f428",
+        "license": "MIT",
+        "skills": 1
+      },
+      "samber/cc-skills-golang": {
+        "repo": "https://github.com/samber/cc-skills-golang",
+        "commit": "4881c01",
+        "license": "MIT",
+        "skills": 1
+      },
+      "aaron-he-zhu/aaron-marketing-skills": {
+        "repo": "https://github.com/aaron-he-zhu/aaron-marketing-skills",
+        "commit": "b7b0b9f",
+        "license": "Apache-2.0",
+        "skills": 1
+      },
+      "ruvnet/claude-code-flow": {
+        "repo": "https://github.com/ruvnet/claude-code-flow",
+        "commit": "73914bd",
+        "license": "MIT",
+        "skills": 2
+      },
+      "ruvnet/ruflo": {
+        "repo": "https://github.com/ruvnet/ruflo",
+        "commit": "73914bd",
+        "license": "MIT",
+        "skills": 2
+      },
+      "basicmachines-co/basic-memory": {
+        "repo": "https://github.com/basicmachines-co/basic-memory",
+        "commit": "53da71c",
+        "license": "custom (see upstream LICENSE)",
+        "skills": 1
+      }
+    },
+    "total_skills": 80,
+    "tiers": {
+      "core": 78,
+      "adjacent": 2
+    }
+  },
+  "provenance": {
+    "items": {
+      "esco": 16,
+      "onet": 67,
+      "jobads": 89,
+      "wiki_ai": 0,
+      "anthropic": 5,
+      "ai_skills": 135,
+      "stackx": 0
+    },
+    "share_percent": {
+      "esco": 5.1,
+      "onet": 21.5,
+      "jobads": 28.5,
+      "wiki_ai": 0.0,
+      "anthropic": 1.6,
+      "ai_skills": 43.3,
+      "stackx": 0.0
+    },
+    "method": "content items per source category"
+  },
+  "collar": "white",
+  "computer_work": true
+}
--- a/references/ai-skills.md
+++ b/references/ai-skills.md
@@ -0,0 +1,258 @@
+# External AI agent skills — clinical-trial-assistant
+
+Proven, publicly available AI agent skills mapped to this occupation.
+Nothing is copied from the sources: every entry is a name, a one-line
+summary and a link to the upstream skill package. Each section names
+its source repository, commit, license and retrieval date.
+
+**Tiers:** `core` = the skill directly exercises a top market hard
+skill, tool or method (from gated job-ad evidence) or an essential
+ESCO competence of this occupation; `adjacent` =
+plausibly useful, secondary. Entries are capped at 12 per source
+and 80 in total per occupation (core first,
+strongest matches survive); everything beyond the caps is excluded
+and logged in the pipeline audit trail, not in this package.
+
+_Matched deterministically (ISCO group + title/competence keywords,
+tiered against market evidence + ESCO essentials) by
+`pipeline/p5_enrich_ai_skills.py` on 2026-07-14._
+
+## Source: anthropics/skills
+
+- Repository: [https://github.com/anthropics/skills](https://github.com/anthropics/skills) (commit `f6656c1`, retrieved 2026-07-14)
+- License: Apache-2.0; the document skills (docx/pdf/pptx/xlsx) are source-available — see the LICENSE.txt in the upstream skill folder
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `docx` | adjacent | Use this skill whenever the user wants to create, read, edit, or manipulate Word documents (.docx files) or Word templates (.dotx files). Triggers include: any mention of 'Word doc', 'word document', '.docx', '.dotx', or requests to … | [source](https://github.com/anthropics/skills/tree/main/skills/docx) |
+| `pdf` | adjacent | Use this skill whenever the user wants to do anything with PDF files. This includes reading or extracting text/tables from PDFs, combining or merging multiple PDFs into one, splitting PDFs apart, rotating pages, adding watermarks, creating … | [source](https://github.com/anthropics/skills/tree/main/skills/pdf) |
+
+## Source: a5c-ai/babysitter
+
+- Repository: [https://github.com/a5c-ai/babysitter](https://github.com/a5c-ai/babysitter) (commit `44a5d58b`, retrieved 2026-07-14)
+- License: MIT
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `medical-coding-audit` | core | Review clinical documentation and assigned codes for accuracy, compliance, and optimization, identifying documentation improvement opportunities and coding errors | [source](https://github.com/a5c-ai/babysitter/tree/44a5d58b/library/specializations/domains/social-sciences-humanities/healthcare/skills/medical-coding-audit) |
+| `population-health-stratification` | core | Stratify patient populations by risk level using claims data, clinical data, and social determinants to prioritize care management interventions | [source](https://github.com/a5c-ai/babysitter/tree/44a5d58b/library/specializations/domains/social-sciences-humanities/healthcare/skills/population-health-stratification) |
+| `bioethics-deliberation` | core | Apply bioethical principles (autonomy, beneficence, non-maleficence, justice) and case-based reasoning to healthcare decisions, research protocols, and clinical dilemmas | [source](https://github.com/a5c-ai/babysitter/tree/44a5d58b/library/specializations/domains/social-sciences-humanities/philosophy/skills/bioethics-deliberation) |
+| `clinical-decision-support-rules` | core | Develop and maintain clinical decision support rules including alerts, reminders, order sets, and evidence-based recommendations within EHR systems | [source](https://github.com/a5c-ai/babysitter/tree/44a5d58b/library/specializations/domains/social-sciences-humanities/healthcare/skills/clinical-decision-support-rules) |
+| `clinical-documentation-query` | core | Generate compliant physician queries to clarify clinical documentation for accurate coding, severity of illness, and risk of mortality capture | [source](https://github.com/a5c-ai/babysitter/tree/44a5d58b/library/specializations/domains/social-sciences-humanities/healthcare/skills/clinical-documentation-query) |
+| `clinical-literature-reviewer` | core | Systematic literature review skill for clinical evaluation supporting regulatory submissions | [source](https://github.com/a5c-ai/babysitter/tree/44a5d58b/library/specializations/domains/science/biomedical-engineering/skills/clinical-literature-reviewer) |
+| `health-data-integration` | core | Facilitate interoperability between health IT systems including EHR, HIE, and clinical decision support through HL7, FHIR, and other healthcare data standards | [source](https://github.com/a5c-ai/babysitter/tree/44a5d58b/library/specializations/domains/social-sciences-humanities/healthcare/skills/health-data-integration) |
+| `clinical-study-designer` | core | Clinical study design skill for medical device trials including IDE studies and post-market studies | [source](https://github.com/a5c-ai/babysitter/tree/44a5d58b/library/specializations/domains/science/biomedical-engineering/skills/clinical-study-designer) |
+| `adverse-event-reporter` | core | Adverse event monitoring and reporting skill for MDR/MEDWATCH compliance | [source](https://github.com/a5c-ai/babysitter/tree/44a5d58b/library/specializations/domains/science/biomedical-engineering/skills/adverse-event-reporter) |
+| `context-engineering` | core | Context window monitoring and budget management. Keeps orchestrator at 15-30% context usage while subagents get full 200k tokens. Provides warnings at thresholds, context-aware summarization triggers, and wave-level budget planning. | [source](https://github.com/a5c-ai/babysitter/tree/44a5d58b/library/methodologies/gsd/skills/context-engineering) |
+| `iec62304-lifecycle-manager` | core | Medical device software lifecycle management skill implementing IEC 62304 requirements | [source](https://github.com/a5c-ai/babysitter/tree/44a5d58b/library/specializations/domains/science/biomedical-engineering/skills/iec62304-lifecycle-manager) |
+| `translation-management` | core | Integration with translation management systems and i18n workflows. Connect with Crowdin, Transifex, Weblate, manage translation memory, synchronize glossaries, and automate localization pipelines. | [source](https://github.com/a5c-ai/babysitter/tree/44a5d58b/library/specializations/technical-documentation/skills/translation-management) |
+
+## Source: aaron-he-zhu/aaron-marketing-skills
+
+- Repository: [https://github.com/aaron-he-zhu/aaron-marketing-skills](https://github.com/aaron-he-zhu/aaron-marketing-skills) (commit `b7b0b9f`, retrieved 2026-07-14)
+- License: Apache-2.0
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `memory-management` | core | Use when the user asks to "remember project context", review saved findings, initialize runtime memory, archive stale work, reconcile notes, or erase a subject; manages authorized HOT/WARM/COLD working memory across all disciplines while … | [source](https://github.com/aaron-he-zhu/aaron-marketing-skills/tree/b7b0b9f/protocol/memory-management) |
+
+## Source: affaan-m/everything-claude-code
+
+- Repository: [https://github.com/affaan-m/everything-claude-code](https://github.com/affaan-m/everything-claude-code) (commit `ed38744`, retrieved 2026-07-14)
+- License: MIT
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `healthcare-cdss-patterns` | core | Clinical Decision Support System (CDSS) development patterns. Drug interaction checking, dose validation, clinical scoring (NEWS2, qSOFA), alert severity classification, and integration into EMR workflows. | [source](https://github.com/affaan-m/everything-claude-code/tree/ed38744/skills/healthcare-cdss-patterns) |
+| `healthcare-emr-patterns` | core | EMR/EHR development patterns for healthcare applications. Clinical safety, encounter workflows, prescription generation, clinical decision support integration, and accessibility-first UI for medical data entry. | [source](https://github.com/affaan-m/everything-claude-code/tree/ed38744/skills/healthcare-emr-patterns) |
+| `agentic-os` | core | Build persistent multi-agent operating systems on Claude Code. Covers kernel architecture, specialist agents, slash commands, file-based memory, scheduled automation, and state management without external databases. | [source](https://github.com/affaan-m/everything-claude-code/tree/ed38744/skills/agentic-os) |
+
+## Source: alirezarezvani/claude-skills
+
+- Repository: [https://github.com/alirezarezvani/claude-skills](https://github.com/alirezarezvani/claude-skills) (commit `0241f43`, retrieved 2026-07-14)
+- License: MIT
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `mdr-745-specialist` | core | EU MDR 2017/745 compliance specialist for medical device classification, technical documentation, clinical evidence, and post-market surveillance. Covers Annex VIII classification rules, Annex II/III technical files, Annex XIV clinical … | [source](https://github.com/alirezarezvani/claude-skills/tree/0241f43/ra-qm-team/skills/mdr-745-specialist) |
+| `research-ops-skills` | core | Use when planning, funding, scoping, or synthesizing enterprise research across workstreams — clinical study design, R&D program finance, market sizing/surveys, or product/user research. Triggers on "design this clinical study", "what … | [source](https://github.com/alirezarezvani/claude-skills/tree/0241f43/research-ops/skills/research-ops-skills) |
+| `clinical-research` | core | — | [source](https://github.com/alirezarezvani/claude-skills/tree/0241f43/.gemini/skills/clinical-research) |
+| `grants` | core | NIH grant research skill for clinical researchers. Grill-me intake (research idea + career stage + preliminary data + environment + submission posture + known institute targets) locks down the funding strategy before any search runs. Runs … | [source](https://github.com/alirezarezvani/claude-skills/tree/0241f43/research/grants/skills/grants) |
+| `quality-documentation-manager` | core | Document control system management for medical device QMS. Covers document numbering, version control, change management, and 21 CFR Part 11 compliance. Use when working on document control procedures, change control workflows, document … | [source](https://github.com/alirezarezvani/claude-skills/tree/0241f43/ra-qm-team/skills/quality-documentation-manager) |
+| `quality-manager-qms-iso13485` | core | ISO 13485 Quality Management System implementation and maintenance for medical device organizations. Provides QMS design, documentation control, internal auditing, CAPA management, and certification support. Use when working with medical … | [source](https://github.com/alirezarezvani/claude-skills/tree/0241f43/ra-qm-team/skills/quality-manager-qms-iso13485) |
+| `capa-officer` | core | CAPA system management for medical device QMS. Covers root cause analysis, corrective action planning, effectiveness verification, and CAPA metrics. Use when running CAPA investigations, 5-Why analysis, fishbone diagrams, root cause … | [source](https://github.com/alirezarezvani/claude-skills/tree/0241f43/ra-qm-team/skills/capa-officer) |
+
+## Source: basicmachines-co/basic-memory
+
+- Repository: [https://github.com/basicmachines-co/basic-memory](https://github.com/basicmachines-co/basic-memory) (commit `53da71c`, retrieved 2026-07-14)
+- License: custom (see upstream LICENSE)
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `memory-tasks` | core | Task management via Basic Memory schemas: create, track, and resume structured tasks that survive context compaction. Uses BM's schema system for uniform notes queryable through the knowledge graph. | [source](https://github.com/basicmachines-co/basic-memory/tree/53da71c/skills/memory-tasks) |
+
+## Source: brycewang-stanford/Auto-Empirical-Research-Skills
+
+- Repository: [https://github.com/brycewang-stanford/Auto-Empirical-Research-Skills](https://github.com/brycewang-stanford/Auto-Empirical-Research-Skills) (commit `85bf545`, retrieved 2026-07-14)
+- License: CC-BY-4.0
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `pharma-skills` | core | 6 pharmaceutical research skills. Trigger: drug discovery, pharmacology, clinical trial design, regulatory filing. Design: end-to-end pipeline from target identification to clinical trials. | [source](https://github.com/brycewang-stanford/Auto-Empirical-Research-Skills/tree/85bf545/skills/43-wentorai-research-plugins/skills/domains/pharma) |
+| `clinical-trial-design-guide` | core | Clinical trial methodology, biostatistics, and study design guidance | [source](https://github.com/brycewang-stanford/Auto-Empirical-Research-Skills/tree/85bf545/skills/43-wentorai-research-plugins/skills/domains/pharma/clinical-trial-design-guide) |
+| `lifelines` | core | Complete survival analysis library in Python. Handles right-censored data, Kaplan-Meier curves, and Cox regression. Standard for clinical trial analysis and epidemiology. | [source](https://github.com/brycewang-stanford/Auto-Empirical-Research-Skills/tree/85bf545/skills/63-tondevrel-scientific-agent-skills/lifelines) |
+| `clinicaltrials-api` | core | Clinical trial registry database search API | [source](https://github.com/brycewang-stanford/Auto-Empirical-Research-Skills/tree/85bf545/skills/43-wentorai-research-plugins/skills/domains/biomedical/clinicaltrials-api) |
+| `biomedical-skills` | core | 24 biomedical research skills. Trigger: medical research, clinical trials, genomics, bioinformatics. Design: domain databases, wet-lab/dry-lab methods, and ethical compliance guides. | [source](https://github.com/brycewang-stanford/Auto-Empirical-Research-Skills/tree/85bf545/skills/43-wentorai-research-plugins/skills/domains/biomedical) |
+| `clinical-research-guide` | core | Design clinical studies and report using CONSORT, STROBE guidelines | [source](https://github.com/brycewang-stanford/Auto-Empirical-Research-Skills/tree/85bf545/skills/43-wentorai-research-plugins/skills/domains/biomedical/clinical-research-guide) |
+| `hud` | core | Diverga HUD (Heads-Up Display) management skill. Configure and manage the research project statusline display. Supports multiple presets: research, checkpoint, memory, minimal. Triggers: "hud", "statusline", "display settings | [source](https://github.com/brycewang-stanford/Auto-Empirical-Research-Skills/tree/85bf545/skills/25-HosungYou-Diverga/skills/hud) |
+| `medical-data-api` | core | Access FDA drug data and WHO global health statistics for research | [source](https://github.com/brycewang-stanford/Auto-Empirical-Research-Skills/tree/85bf545/skills/43-wentorai-research-plugins/skills/domains/biomedical/medical-data-api) |
+
+## Source: davila7/claude-code-templates
+
+- Repository: [https://github.com/davila7/claude-code-templates](https://github.com/davila7/claude-code-templates) (commit `fa79251`, retrieved 2026-07-14)
+- License: MIT
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `clinical-reports` | core | Write comprehensive clinical reports including case reports (CARE guidelines), diagnostic reports (radiology/pathology/lab), clinical trial reports (ICH-E3, SAE, CSR), and patient documentation (SOAP, H&P, discharge summaries). Full … | [source](https://github.com/davila7/claude-code-templates/tree/fa79251/cli-tool/components/skills/scientific/clinical-reports) |
+| `clinicaltrials-database` | core | Query ClinicalTrials.gov via API v2. Search trials by condition, drug, location, status, or phase. Retrieve trial details by NCT ID, export data, for clinical research and patient matching. | [source](https://github.com/davila7/claude-code-templates/tree/fa79251/cli-tool/components/skills/scientific/clinicaltrials-database) |
+| `mdr-745-specialist` | core | EU MDR 2017/745 regulation specialist and consultant for medical device requirement management. Provides comprehensive MDR compliance expertise, gap analysis, technical documentation guidance, clinical evidence requirements, and … | [source](https://github.com/davila7/claude-code-templates/tree/fa79251/cli-tool/components/skills/enterprise-communication/mdr-745-specialist) |
+| `treatment-plans` | core | Generate concise (3-4 page), focused medical treatment plans in LaTeX/PDF format for all clinical specialties. Supports general medical treatment, rehabilitation therapy, mental health care, chronic disease management, perioperative care, … | [source](https://github.com/davila7/claude-code-templates/tree/fa79251/cli-tool/components/skills/scientific/treatment-plans) |
+| `clinical-decision-support` | core | Generate professional clinical decision support (CDS) documents for pharmaceutical and clinical research settings, including patient cohort analyses (biomarker-stratified with outcomes) and treatment recommendation reports (evidence-based … | [source](https://github.com/davila7/claude-code-templates/tree/fa79251/cli-tool/components/skills/scientific/clinical-decision-support) |
+| `biomni` | core | Autonomous biomedical AI agent framework for executing complex research tasks across genomics, drug discovery, molecular biology, and clinical analysis. Use this skill when conducting multi-step biomedical research including CRISPR … | [source](https://github.com/davila7/claude-code-templates/tree/fa79251/cli-tool/components/skills/scientific/biomni) |
+| `quality-manager-qms-iso13485` | core | ISO 13485 Quality Management System specialist for medical device companies. Provides QMS implementation, maintenance, process optimization, and compliance expertise. Use for QMS design, documentation control, management review, internal … | [source](https://github.com/davila7/claude-code-templates/tree/fa79251/cli-tool/components/skills/enterprise-communication/quality-manager-qms-iso13485) |
+| `fda-consultant-specialist` | core | Senior FDA consultant and specialist for medical device companies including HIPAA compliance and requirement management. Provides FDA pathway expertise, QSR compliance, cybersecurity guidance, and regulatory submission support. Use for FDA … | [source](https://github.com/davila7/claude-code-templates/tree/fa79251/cli-tool/components/skills/enterprise-communication/fda-consultant-specialist) |
+| `agent-memory-mcp` | core | A hybrid memory system that provides persistent, searchable knowledge management for AI agents (Architecture, Patterns, Decisions). | [source](https://github.com/davila7/claude-code-templates/tree/fa79251/cli-tool/components/skills/ai-research/agent-memory-mcp) |
+| `it-operations` | core | Manages IT infrastructure, monitoring, incident response, and service reliability. Provides frameworks for ITIL service management, observability strategies, automation, backup/recovery, capacity planning, and operational excellence … | [source](https://github.com/davila7/claude-code-templates/tree/fa79251/cli-tool/components/skills/development/it-operations) |
+
+## Source: foryourhealth111-pixel/Vibe-Skills
+
+- Repository: [https://github.com/foryourhealth111-pixel/Vibe-Skills](https://github.com/foryourhealth111-pixel/Vibe-Skills) (commit `34429a8`, retrieved 2026-07-14)
+- License: Apache-2.0
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `clinical-reports` | core | Write comprehensive clinical reports including case reports (CARE guidelines), diagnostic reports (radiology/pathology/lab), clinical trial reports (ICH-E3, SAE, CSR), and patient documentation (SOAP, H&P, discharge summaries). Full … | [source](https://github.com/foryourhealth111-pixel/Vibe-Skills/tree/34429a8/bundled/skills/clinical-reports) |
+| `clinicaltrials-database` | core | Query ClinicalTrials.gov via API v2. Search trials by condition, drug, location, status, or phase. Retrieve trial details by NCT ID, export data, for clinical research and patient matching. | [source](https://github.com/foryourhealth111-pixel/Vibe-Skills/tree/34429a8/bundled/skills/clinicaltrials-database) |
+| `treatment-plans` | core | Generate concise (3-4 page), focused medical treatment plans in LaTeX/PDF format for all clinical specialties. Supports general medical treatment, rehabilitation therapy, mental health care, chronic disease management, perioperative care, … | [source](https://github.com/foryourhealth111-pixel/Vibe-Skills/tree/34429a8/bundled/skills/treatment-plans) |
+| `clinical-decision-support` | core | Generate professional clinical decision support (CDS) documents for pharmaceutical and clinical research settings, including patient cohort analyses (biomarker-stratified with outcomes) and treatment recommendation reports (evidence-based … | [source](https://github.com/foryourhealth111-pixel/Vibe-Skills/tree/34429a8/bundled/skills/clinical-decision-support) |
+| `iso-13485-certification` | core | Comprehensive toolkit for preparing ISO 13485 certification documentation for medical device Quality Management Systems. Use when users need help with ISO 13485 QMS documentation, including (1) conducting gap analysis of existing … | [source](https://github.com/foryourhealth111-pixel/Vibe-Skills/tree/34429a8/bundled/skills/iso-13485-certification) |
+
+## Source: giuseppe-trisciuoglio/developer-kit
+
+- Repository: [https://github.com/giuseppe-trisciuoglio/developer-kit](https://github.com/giuseppe-trisciuoglio/developer-kit) (commit `306f428`, retrieved 2026-07-14)
+- License: MIT
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `memory-md-management` | core | Provides comprehensive memory file management capabilities including auditing, quality assessment, and targeted improvements for files such as CLAUDE.md. Use when user asks to check, audit, update, improve, fix, maintain, or validate … | [source](https://github.com/giuseppe-trisciuoglio/developer-kit/tree/306f428/plugins/developer-kit-core/skills/memory-md-management) |
+
+## Source: jeremylongshore/claude-code-plugins-plus-skills
+
+- Repository: [https://github.com/jeremylongshore/claude-code-plugins-plus-skills](https://github.com/jeremylongshore/claude-code-plugins-plus-skills) (commit `e112938a`, retrieved 2026-07-14)
+- License: MIT
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `abridge-deploy-integration` | core | Deploy Abridge clinical AI integration to HIPAA-compliant cloud infrastructure. Use when deploying to GCP Cloud Run, AWS ECS, or Azure Container Apps with healthcare-grade secrets management and compliance controls. Trigger: "deploy … | [source](https://github.com/jeremylongshore/claude-code-plugins-plus-skills/tree/e112938a/plugins/saas-packs/abridge-pack/skills/abridge-deploy-integration) |
+| `abridge-cost-tuning` | core | Optimize Abridge clinical AI costs through tier selection, session management, and usage monitoring for healthcare organizations. Use when analyzing Abridge billing, optimizing encounter volume, or right-sizing your Abridge contract for … | [source](https://github.com/jeremylongshore/claude-code-plugins-plus-skills/tree/e112938a/plugins/saas-packs/abridge-pack/skills/abridge-cost-tuning) |
+| `veeva-ci-integration` | core | Veeva Vault ci integration for REST API and clinical operations. Use when working with Veeva Vault document management and CRM. Trigger: "veeva ci integration".  | [source](https://github.com/jeremylongshore/claude-code-plugins-plus-skills/tree/e112938a/plugins/saas-packs/veeva-pack/skills/veeva-ci-integration) |
+| `veeva-common-errors` | core | Veeva Vault common errors for REST API and clinical operations. Use when working with Veeva Vault document management and CRM. Trigger: "veeva common errors".  | [source](https://github.com/jeremylongshore/claude-code-plugins-plus-skills/tree/e112938a/plugins/saas-packs/veeva-pack/skills/veeva-common-errors) |
+| `veeva-core-workflow-a` | core | Veeva Vault core workflow a for REST API and clinical operations. Use when working with Veeva Vault document management and CRM. Trigger: "veeva core workflow a".  | [source](https://github.com/jeremylongshore/claude-code-plugins-plus-skills/tree/e112938a/plugins/saas-packs/veeva-pack/skills/veeva-core-workflow-a) |
+| `veeva-core-workflow-b` | core | Veeva Vault core workflow b for REST API and clinical operations. Use when working with Veeva Vault document management and CRM. Trigger: "veeva core workflow b".  | [source](https://github.com/jeremylongshore/claude-code-plugins-plus-skills/tree/e112938a/plugins/saas-packs/veeva-pack/skills/veeva-core-workflow-b) |
+| `veeva-cost-tuning` | core | Veeva Vault cost tuning for REST API and clinical operations. Use when working with Veeva Vault document management and CRM. Trigger: "veeva cost tuning".  | [source](https://github.com/jeremylongshore/claude-code-plugins-plus-skills/tree/e112938a/plugins/saas-packs/veeva-pack/skills/veeva-cost-tuning) |
+| `veeva-debug-bundle` | core | Veeva Vault debug bundle for REST API and clinical operations. Use when working with Veeva Vault document management and CRM. Trigger: "veeva debug bundle".  | [source](https://github.com/jeremylongshore/claude-code-plugins-plus-skills/tree/e112938a/plugins/saas-packs/veeva-pack/skills/veeva-debug-bundle) |
+| `veeva-deploy-integration` | core | Veeva Vault deploy integration for REST API and clinical operations. Use when working with Veeva Vault document management and CRM. Trigger: "veeva deploy integration".  | [source](https://github.com/jeremylongshore/claude-code-plugins-plus-skills/tree/e112938a/plugins/saas-packs/veeva-pack/skills/veeva-deploy-integration) |
+| `veeva-local-dev-loop` | core | Veeva Vault local dev loop for REST API and clinical operations. Use when working with Veeva Vault document management and CRM. Trigger: "veeva local dev loop".  | [source](https://github.com/jeremylongshore/claude-code-plugins-plus-skills/tree/e112938a/plugins/saas-packs/veeva-pack/skills/veeva-local-dev-loop) |
+| `veeva-performance-tuning` | core | Veeva Vault performance tuning for REST API and clinical operations. Use when working with Veeva Vault document management and CRM. Trigger: "veeva performance tuning".  | [source](https://github.com/jeremylongshore/claude-code-plugins-plus-skills/tree/e112938a/plugins/saas-packs/veeva-pack/skills/veeva-performance-tuning) |
+| `veeva-prod-checklist` | core | Veeva Vault prod checklist for REST API and clinical operations. Use when working with Veeva Vault document management and CRM. Trigger: "veeva prod checklist".  | [source](https://github.com/jeremylongshore/claude-code-plugins-plus-skills/tree/e112938a/plugins/saas-packs/veeva-pack/skills/veeva-prod-checklist) |
+
+## Source: K-Dense-AI/claude-scientific-skills
+
+- Repository: [https://github.com/K-Dense-AI/claude-scientific-skills](https://github.com/K-Dense-AI/claude-scientific-skills) (commit `4d97e29`, retrieved 2026-07-14)
+- License: MIT
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `clinical-reports` | core | Write comprehensive clinical reports including case reports (CARE guidelines), diagnostic reports (radiology/pathology/lab), clinical trial reports (ICH-E3, SAE, CSR), and patient documentation (SOAP, H&P, discharge summaries). Full … | [source](https://github.com/K-Dense-AI/claude-scientific-skills/tree/4d97e29/skills/clinical-reports) |
+| `treatment-plans` | core | Generate concise (3-4 page), focused medical treatment plans in LaTeX/PDF format for all clinical specialties. Supports general medical treatment, rehabilitation therapy, mental health care, chronic disease management, perioperative care, … | [source](https://github.com/K-Dense-AI/claude-scientific-skills/tree/4d97e29/skills/treatment-plans) |
+| `clinical-decision-support` | core | Generate professional clinical decision support (CDS) documents for pharmaceutical and clinical research settings, including patient cohort analyses (biomarker-stratified with outcomes) and treatment recommendation reports (evidence-based … | [source](https://github.com/K-Dense-AI/claude-scientific-skills/tree/4d97e29/skills/clinical-decision-support) |
+| `iso-13485-certification` | core | Comprehensive toolkit for preparing ISO 13485 certification documentation for medical device Quality Management Systems. Use when users need help with ISO 13485 QMS documentation, including (1) conducting gap analysis of existing … | [source](https://github.com/K-Dense-AI/claude-scientific-skills/tree/4d97e29/skills/iso-13485-certification) |
+
+## Source: K-Dense-AI/scientific-agent-skills
+
+- Repository: [https://github.com/K-Dense-AI/scientific-agent-skills](https://github.com/K-Dense-AI/scientific-agent-skills) (commit `4d97e29`, retrieved 2026-07-14)
+- License: MIT
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `clinical-reports` | core | Write comprehensive clinical reports including case reports (CARE guidelines), diagnostic reports (radiology/pathology/lab), clinical trial reports (ICH-E3, SAE, CSR), and patient documentation (SOAP, H&P, discharge summaries). Full … | [source](https://github.com/K-Dense-AI/scientific-agent-skills/tree/4d97e29/skills/clinical-reports) |
+| `treatment-plans` | core | Generate concise (3-4 page), focused medical treatment plans in LaTeX/PDF format for all clinical specialties. Supports general medical treatment, rehabilitation therapy, mental health care, chronic disease management, perioperative care, … | [source](https://github.com/K-Dense-AI/scientific-agent-skills/tree/4d97e29/skills/treatment-plans) |
+| `clinical-decision-support` | core | Generate professional clinical decision support (CDS) documents for pharmaceutical and clinical research settings, including patient cohort analyses (biomarker-stratified with outcomes) and treatment recommendation reports (evidence-based … | [source](https://github.com/K-Dense-AI/scientific-agent-skills/tree/4d97e29/skills/clinical-decision-support) |
+| `iso-13485-certification` | core | Comprehensive toolkit for preparing ISO 13485 certification documentation for medical device Quality Management Systems. Use when users need help with ISO 13485 QMS documentation, including (1) conducting gap analysis of existing … | [source](https://github.com/K-Dense-AI/scientific-agent-skills/tree/4d97e29/skills/iso-13485-certification) |
+
+## Source: mohitagw15856/pm-claude-skills
+
+- Repository: [https://github.com/mohitagw15856/pm-claude-skills](https://github.com/mohitagw15856/pm-claude-skills) (commit `876fa30`, retrieved 2026-07-14)
+- License: MIT
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `clinical-trial-protocol` | core | Draft a clinical trial protocol synopsis with the elements regulators and IRBs expect. Use when asked to write a clinical trial protocol, a study protocol synopsis, a trial design, or to structure endpoints/eligibility/statistics for an … | [source](https://github.com/mohitagw15856/pm-claude-skills/tree/876fa30/plugins/pm-health/skills/clinical-trial-protocol) |
+| `soap-note` | core | Structure a clinical encounter into a clean SOAP note. Use when asked to write a SOAP note, document a patient encounter, turn visit notes into clinical documentation, or structure subjective/objective/assessment/plan. Produces a … | [source](https://github.com/mohitagw15856/pm-claude-skills/tree/876fa30/plugins/pm-health/skills/soap-note) |
+
+## Source: mukul975/Anthropic-Cybersecurity-Skills
+
+- Repository: [https://github.com/mukul975/Anthropic-Cybersecurity-Skills](https://github.com/mukul975/Anthropic-Cybersecurity-Skills) (commit `673da1f`, retrieved 2026-07-14)
+- License: Apache-2.0
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `analyzing-macro-malware-in-office-documents` | core | Analyzes malicious VBA macros embedded in Microsoft Office documents (Word, Excel, PowerPoint) to identify download cradles, payload execution, persistence mechanisms, and anti-analysis techniques. Uses olevba, oledump, and VBA … | [source](https://github.com/mukul975/Anthropic-Cybersecurity-Skills/tree/673da1f/skills/analyzing-macro-malware-in-office-documents) |
+
+## Source: nexu-io/open-design
+
+- Repository: [https://github.com/nexu-io/open-design](https://github.com/nexu-io/open-design) (commit `4b66023`, retrieved 2026-07-14)
+- License: Apache-2.0
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `clinical-case-report` | core | Structured medical case presentation for clinical rounds, conferences, and documentation. Generates SOAP-format or narrative case reports with physiologically accurate vitals, labs, and evidence-based plans. Use when the brief mentions … | [source](https://github.com/nexu-io/open-design/tree/4b66023/design-templates/clinical-case-report) |
+
+## Source: ruvnet/claude-code-flow
+
+- Repository: [https://github.com/ruvnet/claude-code-flow](https://github.com/ruvnet/claude-code-flow) (commit `73914bd`, retrieved 2026-07-14)
+- License: MIT
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `memory-management` | core | AgentDB memory system with HNSW vector search. Provides 150x-12,500x faster pattern retrieval, persistent storage, and semantic search capabilities for learning and knowledge management. Use when: need to store successful patterns, … | [source](https://github.com/ruvnet/claude-code-flow/tree/73914bd/.agents/skills/memory-management) |
+| `AgentDB Memory Patterns` | core | Implement persistent memory patterns for AI agents using AgentDB. Includes session memory, long-term storage, pattern learning, and context management. Use when building stateful agents, chat systems, or intelligent assistants. | [source](https://github.com/ruvnet/claude-code-flow/tree/73914bd/.agents/skills/agentdb-memory-patterns) |
+
+## Source: ruvnet/ruflo
+
+- Repository: [https://github.com/ruvnet/ruflo](https://github.com/ruvnet/ruflo) (commit `73914bd`, retrieved 2026-07-14)
+- License: MIT
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `memory-management` | core | AgentDB memory system with HNSW vector search. Provides 150x-12,500x faster pattern retrieval, persistent storage, and semantic search capabilities for learning and knowledge management. Use when: need to store successful patterns, … | [source](https://github.com/ruvnet/ruflo/tree/73914bd/.agents/skills/memory-management) |
+| `AgentDB Memory Patterns` | core | Implement persistent memory patterns for AI agents using AgentDB. Includes session memory, long-term storage, pattern learning, and context management. Use when building stateful agents, chat systems, or intelligent assistants. | [source](https://github.com/ruvnet/ruflo/tree/73914bd/.agents/skills/agentdb-memory-patterns) |
+
+## Source: samber/cc-skills-golang
+
+- Repository: [https://github.com/samber/cc-skills-golang](https://github.com/samber/cc-skills-golang) (commit `4881c01`, retrieved 2026-07-14)
+- License: MIT
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `golang-security` | core | Security best practices and vulnerability prevention for Golang. Covers injection (SQL, command, XSS), cryptography, filesystem safety, network security, cookies, secrets management, memory safety, and logging. Apply when writing, … | [source](https://github.com/samber/cc-skills-golang/tree/4881c01/skills/golang-security) |
+
+## Source: staruhub/ClaudeSkills
+
+- Repository: [https://github.com/staruhub/ClaudeSkills](https://github.com/staruhub/ClaudeSkills) (commit `3d4045d`, retrieved 2026-07-14)
+- License: MIT
+
+| Skill | Tier | What it adds | Upstream |
+|---|---|---|---|
+| `deep-research` | core | Use this skill when the user wants an evidence-based research memo, literature review, market/policy/technical landscape, or a multi-source decision brief with citations, trade-offs, and a clear conclusion. Best for tasks that need … | [source](https://github.com/staruhub/ClaudeSkills/tree/3d4045d/skills/Geek-skills-deep-research) |
--- a/references/market.md
+++ b/references/market.md
@@ -0,0 +1,140 @@
+# Market evidence report — clinical-trial-assistant
+
+Source: **38 real job ads** (JSearch API, countries: us 38), extracted into the MSSQL evidence store; as of 2026-07-10.
+This report contains extracted, aggregated facts only — no ad text is
+reproduced (copyright / platform terms).
+
+## Seniority distribution
+
+| Seniority | Ads | Share |
+|---|---|---|
+| mid | 17 | 45 % |
+| junior | 15 | 39 % |
+| n/a | 3 | 8 % |
+| senior | 3 | 8 % |
+
+## Tools — full market ranking
+
+| # | Item | Ads | Share |
+|---|---|---|---|
+| 1 | Microsoft Office | 7 | 18 % |
+| 2 | Microsoft Excel | 5 | 13 % |
+| 3 | Microsoft Word | 5 | 13 % |
+| 4 | Microsoft Outlook | 4 | 11 % |
+| 5 | MS Office Suite | 4 | 11 % |
+| 6 | CTMS | 3 | 8 % |
+| 7 | Microsoft PowerPoint | 3 | 8 % |
+
+## Hard skills — full market ranking
+
+| # | Item | Ads | Share |
+|---|---|---|---|
+| 1 | data collection | 9 | 24 % |
+| 2 | data entry | 8 | 21 % |
+| 3 | regulatory compliance | 8 | 21 % |
+| 4 | protocol compliance | 6 | 16 % |
+| 5 | adverse event reporting | 5 | 13 % |
+| 6 | clinical research | 5 | 13 % |
+| 7 | clinical trial monitoring | 5 | 13 % |
+| 8 | clinical trial management | 4 | 11 % |
+| 9 | regulatory document review | 4 | 11 % |
+| 10 | trial master file maintenance | 4 | 11 % |
+| 11 | data management | 3 | 8 % |
+| 12 | data review | 3 | 8 % |
+| 13 | participant screening | 3 | 8 % |
+| 14 | protocol adherence | 3 | 8 % |
+| 15 | source data verification | 3 | 8 % |
+| 16 | study documentation | 3 | 8 % |
+
+## Methods — full market ranking
+
+| # | Item | Ads | Share |
+|---|---|---|---|
+| 1 | good clinical practice (GCP) | 10 | 26 % |
+| 2 | ICH GCP | 4 | 11 % |
+| 3 | standard operating procedures (SOPs) | 4 | 11 % |
+| 4 | FDA regulations | 3 | 8 % |
+
+## Responsibilities — full market ranking
+
+| # | Item | Ads | Share |
+|---|---|---|---|
+| 1 | data management | 3 | 8 % |
+| 2 | data query resolution | 3 | 8 % |
+
+## Regional breakdown
+
+> **Corpus note:** 38 relevant ads in total — below the 100-ad target for a fully reliable ranking. Percentages above should be read as indicative.
+
+### US (us)
+
+38 ads.
+
+**Top hard skills:**
+
+- data collection — 24 % (9 ads)
+- data entry — 21 % (8 ads)
+- regulatory compliance — 21 % (8 ads)
+- protocol compliance — 16 % (6 ads)
+- adverse event reporting — 13 % (5 ads)
+- clinical research — 13 % (5 ads)
+- clinical trial monitoring — 13 % (5 ads)
+- clinical trial management — 11 % (4 ads)
+- regulatory document review — 11 % (4 ads)
+- trial master file maintenance — 11 % (4 ads)
+
+**Top tools:**
+
+- Microsoft Office — 18 % (7 ads)
+- Microsoft Excel — 13 % (5 ads)
+- Microsoft Word — 13 % (5 ads)
+- Microsoft Outlook — 11 % (4 ads)
+- MS Office Suite — 11 % (4 ads)
+- CTMS — 8 % (3 ads)
+- Microsoft PowerPoint — 8 % (3 ads)
+- Clinical Trial Management System (CTMS) — 5 % (2 ads)
+- eDC — 5 % (2 ads)
+- eTMF — 5 % (2 ads)
+
+**Seniority:** mid 45 % · junior 39 % · n/a 8 % · senior 8 %
+
+### UK (gb)
+
+**Insufficient evidence** — 0 ads (minimum for a regional ranking: 30). No ranking is reported for this region.
+
+### EU/DACH (de, at, ch, nl)
+
+**Insufficient evidence** — 0 ads (minimum for a regional ranking: 30). No ranking is reported for this region.
+
+
+## Job title variants in the market
+
+| Title | Ads |
+|---|---|
+| Clinical Research Assistant | 5 |
+| Clinical Trial Assistant | 2 |
+| In-House CRA | 2 |
+| Clinical Research Assistant (3032) - Clinical Research | 1 |
+| Clinical Research Assistant (Temporary) – Eye Research | 1 |
+| Clinical Research Assistant at Temple University Philadelphia, PA | 1 |
+| Clinical Research Assistant I — Hands-On Study Support | 1 |
+| Clinical Research Assistant-Pediatric Phlebotomist | 1 |
+| Clinical Research Associate | 1 |
+| Clinical Research Associate - Part Time | 1 |
+| Clinical Research Associate 3 (537238) | 1 |
+| Clinical Research Associate II | 1 |
+| Clinical Research Associate I-Psychiatry | 1 |
+| Clinical Research Coordinator II - Oncology | 1 |
+| Clinical Trial Assistant (Onsite in Nutley - Hybrid) | 1 |
+| Clinical Trial Assistant I, Clinical Operations | 1 |
+| Clinical Trials Assistant | 1 |
+| Contract Clinical Research Associate | 1 |
+| Evaluator (Clinical Research Assistant ) | 1 |
+| Future Opportunities (Talent Pool) - Clinical Research Associate (CRA) | 1 |
+| In-House Clinical Research Associate | 1 |
+| In-House CRA / Clinical Trial Associate | 1 |
+| Medical Assistant/Clinical Research Assistant- NYC (Temp to Perm) | 1 |
+| Non-licensed Clinical Research Coordinator (Varying Levels); Cancer Center | 1 |
+| Oncology Clinical Research Coordinator | 1 |
+
+Methodology: entities extracted per ad ({hard_skills, tools, methods, responsibilities, seniority}), normalized, counted as DISTINCT ads per entity; report threshold ≥ 3 ads. Headline sections in skills.md/tools.md use the stricter ≥ 20 % threshold.
--- a/references/profile.md
+++ b/references/profile.md
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+# Occupation profile — clinical trial assistant
+
+- **ESCO URI:** http://data.europa.eu/esco/occupation/82b5c6dc-6a4d-4415-80d8-5cfedfc54de7
+- **ESCO code:** 3213.2
+- **ISCO-08 group:** 3213 — Pharmaceutical technicians and assistants
+
+## Description (ESCO)
+
+Clinical trial assistants support clinical drug research. Collaborate with researchers and doctors in hospitals. Manage essential documents such as clinical case report forms, study protocols, and informed consent forms. File relevant logs related to side effects of medicines.
+
+## Definition
+
+nan
+
+## Alternative labels
+
+- clinical research assistant
+- clinical research associate
--- a/references/skills.md
+++ b/references/skills.md
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+# Competences — clinical trial assistant
+
+Source: ESCO v1.2.1 occupation-skill relations (http://data.europa.eu/esco/occupation/82b5c6dc-6a4d-4415-80d8-5cfedfc54de7).
+
+## Essential
+
+- **apply good clinical practices** (skill/competence)
+- **clinical reports** (knowledge)
+- **clinical science** (knowledge)
+- **conduct health related research** (skill/competence)
+- **evidence-based approach in general practice** (knowledge)
+- **maintain treatment records** (skill/competence)
+- **manage healthcare users' data** (skill/competence)
+- **medical studies** (knowledge)
+- **perform clinical coding procedures** (skill/competence)
+- **professional documentation in health care** (knowledge)
+- **record data from biomedical tests** (skill/competence)
+
+## Optional
+
+- clinical coding (knowledge)
+- health records management (knowledge)
+- patient record storage (knowledge)
+- record treated patient's information (skill/competence)
+
+<!-- market-evidence -->
+
+## Market evidence (job-ad analysis, 38 ads, as of 2026-07-10)
+
+Share of analyzed job ads mentioning the item (threshold ≥ 20 %). Source: JSearch/Adzuna APIs.
+
+### Hard skills
+
+- data collection — **24 %**
+- data entry — **21 %**
+- regulatory compliance — **21 %**
+
+### Methods
+
+- good clinical practice (GCP) — **26 %**
+
+<!-- market-evidence -->
--- a/references/tasks.md
+++ b/references/tasks.md
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+# Tasks & work activities — clinical trial assistant
+
+Source: O*NET 30.3, occupation 29-1051.00 (Pharmacists) — manual nearest-occupation mapping via ISCO group 3213; the official ESCO crosswalk has no entry for this ESCO occupation.
+
+## Task statements
+
+- **[Core]** Review prescriptions to assure accuracy, to ascertain the needed ingredients, and to evaluate their suitability.
+- **[Core]** Provide information and advice regarding drug interactions, side effects, dosage, and proper medication storage.
+- **[Core]** Analyze prescribing trends to monitor patient compliance and to prevent excessive usage or harmful interactions.
+- **[Core]** Order and purchase pharmaceutical supplies, medical supplies, or drugs, maintaining stock and storing and handling it properly.
+- **[Core]** Maintain records, such as pharmacy files, patient profiles, charge system files, inventories, control records for radioactive nuclei, or registries of poisons, narcotics, or controlled drugs.
+- **[Core]** Provide specialized services to help patients manage conditions, such as diabetes, asthma, smoking cessation, or high blood pressure.
+- **[Core]** Advise customers on the selection of medication brands, medical equipment, or healthcare supplies.
+- **[Core]** Collaborate with other health care professionals to plan, monitor, review, or evaluate the quality or effectiveness of drugs or drug regimens, providing advice on drug applications or characteristics.
+- **[Core]** Compound and dispense medications as prescribed by doctors and dentists, by calculating, weighing, measuring, and mixing ingredients, or oversee these activities.
+- **[Core]** Refer patients to other health professionals or agencies when appropriate.
+- **[Supplemental]** Prepare sterile solutions or infusions for use in surgical procedures, emergency rooms, or patients' homes.
+- **[Core]** Plan, implement, or maintain procedures for mixing, packaging, or labeling pharmaceuticals, according to policy and legal requirements, to ensure quality, security, and proper disposal.
+- **[Supplemental]** Manage pharmacy operations, hiring or supervising staff, performing administrative duties, or buying or selling non-pharmaceutical merchandise.
+- **[Supplemental]** Work in hospitals or clinics or for Health Management Organizations (HMOs), dispensing prescriptions, serving as a medical team consultant, or specializing in specific drug therapy areas, such as oncology or nuclear pharmacotherapy.
+- **[Core]** Assess the identity, strength, or purity of medications.
+- **[Core]** Teach pharmacy students serving as interns in preparation for their graduation or licensure.
+- **[Supplemental]** Publish educational information for other pharmacists, doctors, or patients.
+- **[Supplemental]** Offer health promotion or prevention activities, such as training people to use blood pressure devices or diabetes monitors.
+- **[Core]** Contact insurance companies to resolve billing issues.
+- **[Supplemental]** Update or troubleshoot pharmacy information databases.
+
+## Detailed work activities
+
+- Advise medical personnel regarding healthcare issues.
+- Advise patients on effects of health conditions or treatments.
+- Analyze chemical compounds or substances.
+- Analyze data to identify trends or relationships among variables.
+- Analyze health-related data.
+- Collaborate with healthcare professionals to plan or provide treatment.
+- Communicate detailed medical information to patients or family members.
+- Determine protocols for medical procedures.
+- Instruct patients in the use of assistive equipment.
+- Maintain inventory of medical supplies or equipment.
+- Maintain medical facility records.
+- Manage healthcare operations.
+- Merchandise healthcare products or services.
+- Order medical supplies or equipment.
+- Prepare medications or medical solutions.
+- Prescribe medications.
+- Prescribe treatments or therapies.
+- Present medical research reports.
+- Process medical billing information.
+- Recommend types of assistive devices.
+- Refer patients to other healthcare practitioners or health resources.
+- Review customer insurance information.
+- Train medical providers.
+- Treat chronic diseases or disorders.
+- Verify accuracy of patient information.
--- a/references/tools.md
+++ b/references/tools.md
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+# Tools & technology — clinical trial assistant
+
+Source: O*NET 30.3, occupation 29-1051.00 (Pharmacists) — manual nearest-occupation mapping via ISCO group 3213; the official ESCO crosswalk has no entry for this ESCO occupation.
+
+| Software | Category | Hot technology |
+|---|---|---|
+| eClinicalWorks EHR software | Medical software | yes |
+| Epic Systems | Medical software | yes |
+| MEDITECH software | Medical software | yes |
+| Microsoft Excel | Spreadsheet software | yes |
+| Microsoft Office software | Office suite software | yes |
+| Microsoft Outlook | Electronic mail software | yes |
+| Microsoft PowerPoint | Presentation software | yes |
+| Microsoft SharePoint | Document management software | yes |
+| Microsoft Word | Word processing software | yes |
+| Computer records systems | Data base user interface and query software |  |
+| Freedom MedTEACH | Computer based training software |  |
+| Healthprolink MedAtlas | Data base user interface and query software |  |
+| Insurance claim processing software | Accounting software |  |
+| Label-making software | Label making software |  |
+| Multitask software | Calendar and scheduling software |  |
+| Pyxis MedStation software | Inventory management software |  |
+| Recordkeeping software | Data base user interface and query software |  |
+| RxKinetics UD Labels for Windows | Label making software |  |
+| TPNassist | Analytical or scientific software |  |
+| TTP LabTech comPOUND | Analytical or scientific software |  |
+| Web browser software | Internet browser software |  |
+
+<!-- market-evidence -->
+
+## Market evidence (job-ad analysis, 38 ads, as of 2026-07-10)
+
+Share of analyzed job ads mentioning the item (threshold ≥ 20 %). Source: JSearch/Adzuna APIs.
+
+### Tools
+
+- Microsoft Office — **18 %**
+
+<!-- market-evidence -->